In the educational context, virtual inclusion faces significant technological, pedagogical, and sociocultural barriers. These include limited digital connectivity, lack of access to technological devices, insufficient inclusive pedagogical strategies among educators, and disparities rooted in ethnicity, gender, language, social class, culture, and disability—factors especially prevalent in marginalized areas. As a result, access to virtual distance education remains limited for many students. This study aims to identify the primary barriers affecting accessibility and usability in digital inclusion. The study employed a qualitative methodology based on a literature review of academic research published between 2020 and 2025. Selection criteria included relevance, coherence, and quality of information, drawing from academic databases such as IEEE Xplore, ACM Library, Springer, SciELO, and ERIC. The findings reveal several recurring barriers: technological inequality, low digital literacy and usability, limited integration of the Universal Design for Learning (UDL) in virtual pedagogy, and insufficient teacher training in inclusive strategies for online learning. However, the literature also highlights key opportunities, such as the expansion of virtual education, the use of assistive technologies, personalized learning, improved access in geographically isolated regions, and the implementation of inclusive educational policies. This analysis underscores that achieving full virtual inclusion requires an integrated approach—one that combines digital innovation, continuous teacher training, and public policies that ensure equitable access and equal opportunities for all students, regardless of their diverse backgrounds