Repository logo
  • English
  • Español
  • Log In
    Have you forgotten your password?
Universidad Tecnológica Indoamérica
Repository logo
  • Communities & Collections
  • Research Outputs
  • Projects
  • Researchers
  • Statistics
  • Investigación Indoamérica
  • English
  • Español
  • Log In
    Have you forgotten your password?
  1. Home
  2. CRIS
  3. Publications
  4. Chemical profiling and cholinesterase inhibitory activity of five phaedranassa herb. (amaryllidaceae) species from ecuador
 
Options

Chemical profiling and cholinesterase inhibitory activity of five phaedranassa herb. (amaryllidaceae) species from ecuador

Journal
Molecules
Date Issued
2020
Author(s)
Moreno R.
Tallini L.R.
Castillo Salazar, David Ricardo
Facultad de Ciencias de la Educación
Osorio E.H.
Montero E.
Bastida J.
Oleas N.H.
León K.A.
Type
Article
DOI
10.3390/molecules25092092
URL
https://cris.indoamerica.edu.ec/handle/123456789/8850
Abstract
It is estimated that 50 million people in the world live with dementia, 60-70% of whom suffer from Alzheimer's disease (AD). Different factors are involved in the development of AD, including a reduction in the cholinergic neurotransmission level. The Amaryllidaceae plant family contains an exclusive, large, and still understudied alkaloid group characterized by a singular skeleton arrangement and a broad spectrum of biological activities. The chemistry and biodiversity of Ecuadorian representatives of the Phaedranassa genus (Amaryllidaceae) have not been widely studied. In this work, five Ecuadorian Phaedranassa species were examined in vitro for their activity towards the enzymes acetyl- (AChE) and butyrylcholinesterase (BuChE), and the alkaloid profile of bulb extracts was analyzed by GC-MS. The species Phaedranassa cuencana and Phaedranassa dubia showed the most AChE and BuChE inhibitory activity, respectively. To obtain insight into the potential role of the identified alkaloids in these inhibitory effects, docking experiments were carried out, and cantabricine showed in silico inhibitory activity against both cholinesterase structures. Our results show that Amaryllidaceae species from Ecuador are a potential source of new drugs for the palliative treatment of AD. © 2020 by the authors.
Subjects
  • Countries; E-Governme...

Views
5
Acquisition Date
May 8, 2025
View Details
google-scholar
Downloads
Logo Universidad Tecnológica Indoamérica Hosting and Support by Logo Scimago

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science

  • Cookie settings
  • Privacy policy
  • End User Agreement
  • Send Feedback