In the current context, entrepreneurship requires extensive knowledge for proper development. In Latin America, the lack of expertise in areas such as marketing and financial management leads to a high rate of business failure. This study addresses this issue by implementing a virtual learning environment called Emprende Virtual, designed to promote sustainable entrepreneurship through masterclasses and practical activities. The methodology used was a quantitative approach with an experimental design. A total of 59 participants were divided into two groups: an experimental group that received training through the digital resource of the virtual environment and a control group that received no intervention. Pre- and post-test surveys were conducted to measure the impact of the virtual learning environment on the participants’ entrepreneurial attitude, knowledge and skills. The results showed a significant improvement in the experimental group compared to the control group, especially in areas such as educational technology, innovation and entrepreneurship, and business management. This demonstrates that the strategy not only facilitates access to education but also contributes to the development of essential skills for business success, promoting sustainability and economic growth. Despite limitations such as the lack of geographical representativeness and variability in prior experience, the VLE proves to be an effective tool for developing entrepreneurs in the region.