Sánchez Redrobán, José
Preferred name
Sánchez Redrobán, José
Main Affiliation
Quito
ORCID
0000-0003-4571-1618
Scopus Author ID
59772297900
13 results
Now showing 1 - 10 of 13
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Item type:Publication, Political stability, health system resilience, and macroeconomic shocks as factors associated with malaria control outcomes: a comparative analysis of Ecuador and Venezuela (2000–2023)(Springer Science and Business Media LLC, 2026-06-20); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Kabisa: A Support for Teaching Decision Making in Medicine, Comparative Study(Springer Nature Switzerland, 2026); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effective Reproduction Number (Re) Analysis of BCG Vaccination Impact on Tuberculosis Control in Ecuador: An Artificial Intelligence Approach with Sensitivity AnalysisBackground: Tuberculosis remains a major public health challenge globally, with Ecuador reporting significant burden despite vaccination programs. The effective reproduction number provides insights into transmission dynamics under control measures. Methods: We developed a modified SVIR (Susceptible-Vaccinated-Infected-Recovered) compartmental model using Bayesian optimization to analyze BCG vaccination impact on TB transmission in Ecuador during 1995–2007. We calculated effective reproduction numbers (Re) and conducted comprehensive sensitivity analyses to quantify vaccination program effectiveness while accounting for parameter uncertainty. Results: Our analysis revealed an average effective reproduction number (Re) of 0.003 (95% CI: 0.002–0.004), indicating well-controlled transmission dynamics. The model estimated that BCG vaccination contributed to an average reduction of 54.59 cases per 100,000 population (49.65% reduction; 95% CI: 45.2–54.1%) compared to counterfactual scenarios without vaccination. Sensitivity analysis confirmed robustness of findings across parameter variations, with vaccine efficacy estimates ranging from 40–60% producing similar results. Conclusions: Ecuador’s universal BCG vaccination policy significantly contributed to TB control during the study period. However, the observed low Re values reflect the combined effect of vaccination, case detection, and treatment programs rather than vaccination alone. These findings support continued vaccination within comprehensive TB control strategies while acknowledging the need for complementary interventions. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2026. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Risk Factors Associated with Hyporesponsiveness to Erythropoietin in Chronic Kidney Disease Patients on Hemodialysis Who Present Anemia: A Multicenter Case-Control Study(2025)36 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Drug-Resistant Tuberculosis in Prisons of Latin America and the Caribbean: A Critical Reflection on Structural Challenges and GapsDrug-resistant tuberculosis (DR-TB) represents a major public health threat, particularly in the prisons of Latin America and the Caribbean, where rates are up to 40 times higher than those observed in the general population. These facilities act as community amplifiers due to overcrowding, poor ventilation, diagnostic delays, and treatment discontinuity. This study offers a critical reflection on the magnitude, determinants, and implications of DR-TB in regional penitentiary contexts. A reflective analytical review was conducted in PubMed, Scopus, Web of Science, SciELO, and LILACS, complemented by WHO and PAHO reports, prioritising studies from 2019 to 2024. The findings reveal MDR-TB and pre-extensively drug-resistant (pre-XDR) outbreaks in Peru, Paraguay, and the Dominican Republic, as well as community transmission linked to prisons in Brazil and Colombia. Persistent gaps remain in systematic screening, drug susceptibility testing coverage, and post-release follow-up. Scientific production continues to be uneven and predominantly biomedical, with limited consideration of social and human rights determinants. DR-TB in prisons reflects the structural deficiencies of health and justice systems; its control requires intersectoral policies, genomic surveillance, and strategies that ensure early diagnosis, treatment continuity, and dignified detention conditions. © 2026 by the authors.6 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A comprehensive framework for integrating modern educational technologies with problem-based learning in medical education(2025); Monserrat Vanessa Romero-DuranProblem-Based Learning (PBL) has evolved from its traditional roots into a sophisticated pedagogical approach enhanced by advanced digital technologies, including artificial intelligence as a subset of these digital innovations. This comprehensive framework provides medical educators with evidence-based guidance for implementing technology-enhanced PBL methodology, incorporating both traditional principles and modern technological tools. We synthesize current literature from 2019 to 2025, analyzing research findings to create actionable recommendations for educators seeking to implement or improve their PBL programs. Recent studies demonstrate significant improvements through technology integration: 34% enhancement in diagnostic accuracy (Yang et al. in J Pharm Educ Pract 12:112–120, 2024), 28% better knowledge retention (Yan et al. in BMC Med Educ 23:456, 2023), and 42% increase in student engagement (Matsuda and Izumi in Med Educ Online 29:2345, 678, 2024). The integration of virtual patients, simulation-based learning, and adaptive systems shows promising results in enhancing traditional PBL methodologies while maintaining core pedagogical principles. Our proposed framework addresses implementation planning, role definitions, assessment strategies, and quality assurance mechanisms that medical educators can immediately apply across diverse cultural and institutional contexts. © The Author(s) 2025.14 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Natural Language Processing Applied to Emotion Analysis for Continuous Improvement in Industrial EnvironmentsThe objective of this study was to analyze emotions expressed in natural language within Ecuadorian industrial environments using natural language processing (NLP) techniques. A sample of 150 anonymized texts was used, extracted from workplace climate surveys, satisfaction forms, operational reports, and digital suggestion boxes from companies in the manufacturing, food, logistics, health, education, and technology sectors. The texts were processed with an NLP pipeline using the spaCy library for cleaning, tokenization, and lemmatization, and semantically represented pre-trained models such as multilingual BERT and Emotion BERT. Supervised classification identified six emotions: joy, sadness, anger, fear, surprise, and neutrality. Statistical analysis revealed that the most frequent emotion was neutrality (34% of the total), followed by joy (21%), sadness (18%), anger (12%), fear (10%), and surprise (5%). At the sectoral level, logistics was the sector with the highest proportion of joy (28%), followed by food (24%) and manufacturing (12%). Manufacturing, on the other hand, had the highest proportions of sadness (20%) and anger (18%). The temporal analysis of positive sentiment between January and June 2025 showed a sustained increase in the technology sector, which rose from 62% to 77%. The healthcare sector showed an oscillating curve, falling from 58% to 56% in March and recovering to 63% in June. Education showed a cyclical pattern between 49% and 54%, related to its institutional calendar. In contrast, manufacturing remained stable but low, fluctuating between 40% and 42%. These results show that PLN allows us to capture structural emotional differences between sectors, and that these emotions can be correlated with internal dynamics of recognition, workload, or participation. It is concluded that automated emotional analysis is a useful tool for monitoring the organizational climate, anticipating psychosocial risks, and designing tailored intervention strategies. Its systematic application is recommended in organizations with digitized internal communication structures, especially in sectors with high turnover or emotional vulnerability. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2026.11 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The pharmaceutical industry’s multifaceted role in neglected tropical disease control: from market failure to global health innovationBackground: Neglected tropical diseases (NTDs) represent a profound market failure wherein pharmaceutical innovation systematically underserves populations with the greatest need. Despite affecting over 1.7 billion people globally, NTDs receive less than 2% of pharmaceutical research and development (R&D) investment. Objective: This review synthesises evidence on the pharmaceutical industry’s evolving role in NTD control, examining both traditional commercial models and innovative partnerships that have reshaped the global health landscape, with particular attention to implementation mechanisms and concrete operational pathways. Methods: We conducted a comprehensive analysis of WHO reports, G-FINDER data, peer-reviewed literature, and industry commitments spanning 2000–2024, focusing on drug development pipelines, mass drug administration programmes, and financing mechanisms. Results: Product Development Partnerships (PDPs) have delivered 183 approved products since 1999, though the majority represent reformulations or repurposed compounds rather than novel chemical entities (NCEs). Mass drug administration programmes have distributed over 17 billion treatments from pharmaceutical donations valued at approximately $30 billion (at wholesale prices), preventing millions of disability-adjusted life years. However, persistent innovation gaps remain: only 4 NCEs (0.5% of all new therapeutics 2000–2011) specifically targeted NTDs. Diagnostic development continues to lag due to commercial barriers and fragmented regulatory pathways. Conclusions: The pharmaceutical industry’s contribution to NTD control has evolved from minimal engagement to strategic partnerships blending philanthropic drug donation, nonprofit-led R&D, and market-based incentives. While mechanisms including Priority Review Vouchers and Advance Market Commitments show potential, their effectiveness remains debated in the literature, particularly regarding access provisions and additionality. Future progress requires sustained push funding for PDPs, multi-year donor commitments, expansion of WHO prequalification for diagnostics, and strengthened South–South technology-transfer partnerships with concrete implementation frameworks. © The Author(s) 2026. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Epidemiological trends of leishmaniasis in the Metropolitan District of Quito, Ecuador (2015–2021): implications for public health surveillance(Informa UK Limited, 2026-07-10); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A Narrative Review of Human Papillomavirus (HPV) Vaccination in Ecuador: A Crisis of Inequity and an Evidence-Based Roadmap for Elimination(2025); ; Carlos SantillanBackground: Human Papillomavirus (HPV) remains the leading cause of cervical cancer in Ecuador, which suffers from systemic programmatic failures that undermine the global elimination strategy. Crisis: Ecuador’s HPV vaccination coverage (35.6% first dose; 17.3% complete) is the lowest in Latin America, starkly contrasting with the WHO’s 90% target for cervical cancer elimination (Pan American Health Organization 2025). Structural inequities, a profound genotypic mismatch with the circulating quadrivalent vaccine (HPV 58/31/52 prevalence), and fragmented implementation perpetuate this public health crisis (Jose Ortiz Segarra et al. Infectious Disease Reports, 15(3):267–278 2023). Key Findings: Our analysis reveals that the nation’s health-center-based model fails to reach vulnerable populations, a problem exacerbated by critical cold chain deficiencies in 30% of facilities. In contrast, regional successes, such as Peru’s school-based programs (94% coverage) and Colombia’s strategic adoption of the nonavalent vaccine, offer a clear roadmap for reform (Pan American Health Organization 2025, María Ines Sarmiento-Medina et al. PLOS ONE, 19(2):e0297579 2024). Recommendations: We propose an evidence-based 5-point plan to overhaul Ecuador’s strategy: a targeted nonavalent vaccine pilot, immediate adoption of a single-dose schedule, culturally adapted self-sampling programs, phased-in gender-neutral vaccination, and urgent investment in cold chain infrastructure28