Among the challenges the human population needs to address are threats of global pandemics, increasing socioeconomic inequality, especially in developing countries, and anthropogenic climate change. The latter’s effect has been amplified with the arrival of 2023/24 El Niño, causing an exceptional drought in the Amazon basin, significantly affecting fire conditions and hydroelectric power production in several South American countries, including Ecuador. This study analyzes five criteria pollutants—carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3), and particulate matter ≤ 2.5 µm (PM2.5)—during 2019–2024 in Quito, Ecuador, a high-elevation tropical metropolis. Despite long-term efforts to regulate emissions, air pollution levels continue to rise, driven by overlapping crises, including energy shortages, political unrest, and extreme weather events. The persistent failure to improve air quality underscores the vulnerability of developing nations to climate change-induced energy instability and the urgent need for adaptive, diversified, and resilient future energy planning. Without immediate shifts in climate adaptation policies, cities like Quito will continue to experience worsening air quality, with severe implications for public health and environmental sustainability.