Oleas Gallo, Nora Helena
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Preferred name
Oleas Gallo, Nora Helena
Main Affiliation
Quito
Email
noraoleas@uti.edu.ec
ORCID
Scopus Author ID
12645534600

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Alkaloid Profiling and Anti-Cholinesterase Potential of Three Different Genera of Amaryllidaceae Collected in Ecuador: Urceolina Rchb., Clinanthus Herb. and Stenomesson Herb.

2024 , Luciana R. Tallini , Karen Acosta León , Raúl Chamorro , Edison H. Osorio , Jaume Bastida , Lou Jost , Oleas Gallo, Nora Helena

Ecuador is an important center of biodiversity for the plant subfamily Amaryllidoideae, known for its important bioactive molecules. This study aimed to assess the chemical and biological potential of four different Amaryllidoideae species collected in Ecuador: Urceolina formosa, Urceolina ruthiana, Clinanthus incarnatus, and Stenomesson aurantiacum. Twenty-six alkaloids were identified in the bulb extracts of these species using GC-MS. The extract of S. aurantiacum exhibited the greatest structural diversity and contained the highest amounts of alkaloids, particularly lycorine and galanthamine. Only for this species, identification of all the alkaloids belonging to this chemical profile was not possible. Six of them remain unidentified. The potential of these three Amaryllidoideae genera against Alzheimer’s disease was then evaluated by measuring their AChE and BuChE inhibitory activity, revealing that C. incarnatus and U. formosa (from Sucumbíos province) showed the best results with IC50 values of 1.73 ± 0.25 and 30.56 ± 1.56 µg·mL−1, respectively. Molecular dynamic assays were conducted to characterize the possible interactions that occurs among 2-hydroxyanhydrolycorine and the AChE enzyme, concluded that it is stabilized in the pocket in a similar way to galanthamine. This study expands our understanding of the biodiversity of Amaryllidoideae species from Ecuador, highlighting their potential as source of chemical compounds with pharmaceutical applications.

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First records of the genus Pyrolirion Herb. (Liliopsida, Asparagales, Amaryllidaceae) in Ecuador

2025 , Oleas Gallo, Nora Helena , Lou Jost , Ricardo Zambrano C. , Cristian Guzmán Torres , Jorge Heredia , Martin Bustamante , Hugo Romero-Saltos , María Paulina Moreno-Armijos , Alan W. Meerow , Catalina Quintana

We report for the first time in Ecuador the small plant genus Pyrolirion Herb. (Amaryllidaceae). We identify several Ecuadorian populations of Pyrolirion tubiflorum (L’Hér.) M. Roem. located in four provinces along the Ecuadorian Andes. This species has been previously recorded in Peru, Bolivia, and Chile. An updated description of P. tubiflorum is provided, along with detailed photographs of some of the Ecuadorian examples of the species.

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