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    CBCT-guided Caldwell–Luc management of a dentigerous cyst associated with an ectopic maxillary third molar in the maxillary sinus: a case report
    (Frontiers Media SA, 2026-08-04)
    Llanos-Arteaga, José Luis
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    Delgado-Piedra, Daniel Andrés
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    Llanos-Arteaga, Luis Alberto
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    Llanos-Arteaga, Anderson Daniel
    ;
    A dentigerous cyst associated with an ectopic third molar in the maxillary sinus is an extremely rare pathological entity that poses diagnostic and therapeutic challenges. We report the case of a 22-year-old woman with a four-month history of chronic nasal congestion and postnasal drip sensation, without a relevant medical history. Cone-beam computed tomography (CBCT) confirmed a cystic lesion associated with an ectopic third molar, allowing accurate three-dimensional assessment for surgical planning, with partial involvement of the left maxillary antrum. Given the size and location of the lesion, complete cystic capsule enucleation and ectopic tooth odontectomy were performed using the Caldwell–Luc approach under local anesthesia. Histopathological examination confirmed the diagnosis of a dentigerous cyst. Clinical and imaging follow-up at six months showed complete resolution of sinonasal symptoms and no evidence of recurrence. This case highlights that the Caldwell–Luc approach guided by CBCT remains a viable and effective option for treating extensive odontogenic cystic lesions involving the maxillary sinus. © 2026 Llanos-Arteaga, Delgado-Piedra, Llanos-Arteaga, Llanos-Arteaga and Parise-Vasco.
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    Reconstructing severe acute respiratory infection dynamics from ICD-10 hospital discharge data: a 10-year analysis of 11.2 million discharges in Ecuador, 2014–2023
    (Frontiers Media SA, 2026-07-22) ; ; ;
    Fuentes-Tumbaco, Natasha Bella
    ;
    Escobar-Naranjo, Mónica
    Background – In many low- and middle-income countries, surveillance of severe acute respiratory infections (SARI) relies on administrative hospital data without virological confirmation, and its ability to capture epidemic dynamics and age-specific burden remains uncertain. Methods – We analyzed 11, 232, 698 hospital discharges recorded by Ecuador's National Institute of Statistics and Censuses between 2014 and 2023, identified SARI episodes using International Classification of Diseases, 10th Revision (ICD-10) codes under broad and length-of-stay–restricted case definitions, and incorporated a neonatal component that included perinatal respiratory codes for infants younger than 1 year. Serfling harmonic regression was used to estimate seasonal baselines and excess SARI admissions at national, provincial, and age-stratified levels. Results – Administrative data identified 538, 272 SARI discharges and revealed marked heterogeneity in incidence and case fatality across provinces and age groups. A previously unrecognized shift in ICD-10 coding from respiratory to perinatal chapters produced an apparent 99% decline in infant SARI after 2014; reclassifying perinatal respiratory codes restored stable high SARI rates in infants and increased their estimated burden by nearly ten-fold. Nationally, we identified 50 epidemic weeks with 77, 352 excess SARI discharges (95% CI 70, 030–85, 982), while the COVID-19 pandemic disrupted typical seasonality, reducing admissions but increasing mortality among older adults. Conclusions – Routinely collected hospital discharge data can reconstruct SARI epidemic dynamics and geographic disparities in the absence of virological surveillance, but are highly sensitive to coding practices. Incorporating neonatal perinatal respiratory codes into SARI definitions is essential to avoid underestimating infant burden and misinforming public health priorities. Copyright © 2026 Angamarca-Iguago, Cagua-Ordónez, Parise-Vasco, Fuentes-Tumbaco, Escobar-Naranjo, Reytor-González and Simancas-Racines.
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    Artificial intelligence in physical examination teaching in Latin America: a critical narrative review and conceptual model proposal
    (Frontiers Media SA, 2026-04-13) ;
    González, Paloma
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    Fors, Martha
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    Artificial intelligence (AI) is reshaping medical education, particularly in the teaching of physical examination and the development of clinical judgement in digitally mediated contexts. This study presents a critical narrative review examining the ethical, pedagogical, and humanistic implications of AI integration into physical examination training in Latin America. A structured search of literature published between 2018 and 2025 was conducted across PubMed, Scopus, Web of Science, SciELO, and Google Scholar. Thirty-one peer-reviewed studies and three institutional documents met predefined relevance criteria and were analyzed through thematic synthesis. Four thematic domains emerged: (1) AI-assisted clinical simulation and automated feedback, (2) curricular integration and institutional implementation strategies, (3) governance and ethical supervision frameworks, and (4) emerging challenges related to digital literacy, technological dependence, and preservation of clinical judgement. Evidence suggests that AI enhances procedural precision and formative feedback; however, its educational value remains complementary and dependent on structured human-in-the-loop supervision. Based on these findings, the Modelo Educativo Digital basado en Inteligencia Artificial (or Medical Education with Artificial Intelligence) (MED-IA) conceptual model is proposed, framing clinical competence development across three interconnected levels: technical execution, experiential patient interaction, and reflective judgement. The model integrates technological mediation with ethical oversight and humanistic formation. These findings highlight the need for transparent governance frameworks, teacher digital literacy, and context-sensitive institutional policies to ensure responsible AI implementation in Latin American medical education. Copyright © 2026 Torres, González, Fors and Trujillo.
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    Perception, knowledge and attitudes of Ecuadorian dentists towards patients with molar incisor hypomineralization
    (Frontiers Media SA, 2026-06-08)
    Armas-Vega, Ana
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    ; ; ;
    Ribadeneira-Morales, Jennifer
    Background – Molar Incisor Hypomineralization (MIH) is one of the most prevalent enamel development defects in contemporary dental practice. Understanding perceptions, knowledge, and attitudes of professionals towards this condition is key to optimizing clinical protocols and improving therapeutic results. Objective – To evaluate the perception, knowledge and attitudes of Ecuadorian dentists about diagnosis and management of patients with MIH. Methods – A cross-sectional observational study was carried out using a self-administered survey of registered dentists in Ecuador. A validated 19-question questionnaire was applied that explored demographic characteristics, knowledge of etiology and prevalence, attitudes towards clinical management, and therapeutic choices. In addition, two clinical cases with photographic support were included to evaluate treatment decisions. The statistical analysis incorporated descriptive statistics, chi-square or Fisher's exact tests, and multivariate logistic regression models. Results – A total of 352 dentists participated, predominantly working in private practice (71.9%), particularly in general dentistry (61.1%). Most practitioners reported observing MIH monthly (45.7%) and perceived an increase in its occurrence (67.0%). Demarcated opacities were the most frequent clinical manifestation (93.2%), with antibiotics being the main reported etiological factor (31.8%). The frequency of observation varied significantly between specialties (p < 0.05). Management was considered difficult, with durability of restorations being the main concern. Glass ionomer (37.5–71.4%) was the primary therapeutic choice, followed by fluoride varnish (22.6–37.5%). In the multivariate logistic regression model, professionals with 6–10 years of experience showed significantly higher odds of adequate knowledge (adjusted OR = 2.23, 95% CI: 1.14–4.37, p = 0.019). No independent predictors of favorable attitude towards MIH management reached statistical significance after multivariate adjustment. Conclusions – MIH is recognized as a growing and complex problem. It is frequently observed with demarcated opacities as the predominant sign and antibiotics as the main etiological factor. Its management is challenging, and professional experience appears to influence clinical knowledge. Continuing education and the development of standardized clinical protocols are needed to strengthen professional competence in MIH management. © 2026 Armas-Vega, Parise-Vasco, Angamarca-Iguago, Cagua-Ordoñez, Reytor-González, Ribadeneira-Morales, Rösing, Noal and Simancas-Racines.
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    Bullying and cyberbullying victimization and associated mental health and behavioral risks among adolescents in Ecuador
    (Frontiers Media SA, 2026-04-28)
    Fors, Martha
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    Gonzalez, Paloma
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    Massuht, Fresia
    Introduction Bullying remains a major public health concern among adolescents and is associated with adverse mental health and behavioral outcomes. Evidence from low- and middle-income countries, including Ecuador, remains limited. Methods We conducted a cross-sectional study using data from the Ecuadorian version of the Youth Risk Behavior Surveillance System (YRBSS). Associations between school bullying, cyberbullying, and emotional distress (sadness), suicidal behaviors (ideation, planning, attempts), and risk behaviors (alcohol use, marijuana use, and school fights) were assessed using chi-square tests and logistic regression. Odds ratios (OR) and relative risks (RR) with 95% confidence intervals (CI) were calculated. Results Among 300 adolescents, 10.0.3% reported school bullying and 16.0% reported cyberbullying. Bullying victimization was associated with higher odds of sadness (OR 3.33, 95% CI 1.50–7.35), suicidal ideation (OR 431, 1.99–9.0.32), suicidal planning (OR 5.45, 2.51–1183), and suicide attempts (OR 5.43, 2.39–12.36). Cyberbullying was strongly associated with alcohol consumption (RR 5.33, 95% CI 2.47–11.46) and marijuana use (RR 7.20, 1.86–27.92). Discussion Bullying and cyberbullying are strongly associated with emotional distress, suicidal behaviors, and substance use among adolescents in Ecuador. These findings underscore the urgent need for school-based prevention strategies and integrated public health interventions targeting adolescent mental health.
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    Serum Low-Density Lipoprotein Cholesterol and Neck Disability Among University Employees: A Cross-Sectional Study
    (MDPI AG, 2026-09-01)
    Rodríguez-Mata, Nathaly Alejandra
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    Iñiguez-Jimenez, Samuel Olegario
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    Vinueza-Fernández, Israel Santiago
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    Background: Neck pain is a common cause of work-related disability, yet the relationship between serum low-density lipoprotein cholesterol (LDL-C) and neck disability remains uncertain. This study examined whether serum LDL-C was independently associated with neck disability among university employees. Methods: A cross-sectional secondary analysis was conducted using occupational health records from 236 administrative and teaching employees of a private university in Quito, Ecuador. Neck disability was assessed using the Spanish-language Neck Disability Index (NDI). Serum LDL-C was analyzed as a continuous variable (per 10 mg/dL increase). The primary analysis used proportional-odds ordinal logistic regression adjusted for sex, age group, education level, and job position. Model assumptions, multicollinearity, influence, and stability were evaluated. Sensitivity analyses included a three-level ordinal model, multiple linear regression with the continuous NDI score, and nonparametric bootstrap resampling. Results: Mean LDL-C was 112.42 ± 29.09 mg/dL, and 56 participants (23.73%) had LDL-C concentrations ≥ 130 mg/dL. Mild neck disability was the most common category (58.05%), whereas severe disability was uncommon (1.27%). Serum LDL-C was not independently associated with higher neck disability in the adjusted ordinal model (adjusted OR per 10 mg/dL = 0.956; 95% CI, 0.876–1.043; p = 0.309). Sensitivity analyses using alternative-outcome specifications and bootstrap resampling produced consistent findings. Female sex was independently associated with greater disability, whereas no other covariates reached statistical significance. Conclusions: Serum LDL-C was not independently associated with neck disability in this selected occupational population after adjustment for demographic and occupational factors. Prospective multicenter studies incorporating broader cardiometabolic, inflammatory, ergonomic, behavioral, and psychosocial variables are needed to further clarify determinants of neck disability. © 2026 by the authors.
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    Distinguishing Isolated From Familial Microtia: Demographic, Clinical, and Anatomical Insights From Ecuador
    (SAGE Publications, 2026-06-29) ;
    Coello, Fausto
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    Ortiz-Campoverde, Pamela Estefanía
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    Vásconez, Henry
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    Aguinaga-Romero, Gabriela
    Background: Microtia is a congenital defect of the external ear, ranging from structural auricular deficiency to anotia, and is frequently associated with hearing impairment. Its prevalence varies geographically, with notably higher rates reported in high-altitude regions of Ecuador. However, clinical, and anatomical comparisons between isolated and familial microtia in Ecuador remain limited. Objective: To analyze the demographic, clinical, and anatomical characteristics of Ecuadorian patients with microtia, emphasizing differences between isolated and familial cases. Methods: A cross-sectional observational study was conducted in 2024, including 146 patients with confirmed microtia. Patients were classified as isolated or familial according to family history. Demographic, clinical, anatomical, and audiological variables were collected. Minor auricular findings, including auricular nodules, preauricular sinus, Darwin tubercle, and prominent ear, were recorded separately as associated anatomical observations and were not considered diagnostic criteria or severity indicators. Data were analyzed using descriptive statistics, chi-square, and Mann-Whitney tests, and multivariate logistic regression. Results: Median age was 10 years (IQR 8-14), with no significant age differences between groups. Isolated microtia was more frequent in males than familial microtia (72.32% vs 52.94%; P = .034). Familial cases showed more Grade 1 right-ear microtia (26.7% vs 11%; P = .003), whereas isolated cases more commonly presented Grade 3 microtia. Left auricular nodules, or mamelons, were significantly associated with isolated microtia (P = .024; OR = 8.07; 95% CI: 1.05-62.24). Conclusion: Isolated and familial microtia showed distinct demographic and anatomical patterns. Auricular nodules were associated with isolated microtia but should be interpreted as associated anatomical findings, not diagnostic or severity markers. © The Author(s) 2026
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    Promise, Mimicry, and Surveillance: Responsibly Integrating Artificial Intelligence With Socratic Inquiry in Medical Education
    (JMIR Publications Inc., 2026-09-10)
    Large language models are increasingly proposed as a way to deliver Socratic dialogue at scale in medical education, offering personalized, always-available, and lower-stakes inquiry that human educators cannot logistically provide. In this viewpoint, I argue that this promise is plausible but unproven and that 2 failure modes deserve more attention than they currently receive. The first is the mimicry trap: a system that fluently generates Socratic-sounding questions can appear to cultivate reasoning while functioning as interactive content delivery. I position this as an educational instance of the ELIZA effect and of the proxy-outcome problem; separating conversational mimicry from genuine metacognitive gain remains a central unresolved evaluation problem. The second is what I term the Panopticon Paradox: the data collection that makes AI tutoring effective may erode the psychological safety that Socratic inquiry requires, pushing learners toward performative rather than authentic engagement, in a manner analogous to gaming behaviors documented in intelligent tutoring systems. I present this second construct as a testable causal model with specified mediators, moderators, and falsifiable predictions rather than as an established finding. Because the evidence base is dominated by proof-of-concept tools, cross-sectional surveys, and short-term evaluations, I argue that AI is complementary rather than a replacement technology, and I propose a 3-pillar framework (governance, curriculum, and faculty development) tied explicitly to the 2 failure modes. I distinguish 4 modalities of delegation and argue that ethical deliberation, emotionally complex communication, and ambiguous clinical judgment cannot presently be recommended for autonomous or primary AI delivery. © 2026 JMIR Publications Inc.. All rights reserved.
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    Paradoxes of Elimination and Persistence: Neglected Tropical Diseases in Ecuador Compared to Latin America and the Caribbean
    (Wiley, 2026-01) ;
    Chowdhury, Rajib
    Objective To describe, from a comparative Latin American perspective, the progress and gaps in the elimination of neglected tropical diseases (NTDs) in Ecuador, integrating recent data on arboviruses, American trypanosomiasis, leishmaniasis, and structural determinants such as water, sanitation, and hygiene (WASH). Methods A narrative review with a descriptive comparison of secondary data based on secondary sources published between 2015 and 2026. Sources were identified through structured searches of PubMed/MEDLINE, the PAHO Institutional Repository for Information Sharing (IRIS), the WHO Global Health Library, and the WHO/UNICEF Joint Monitoring Programme (JMP) data portal, supplemented by targeted retrieval of official technical reports from WHO, PAHO, UNICEF, and Ecuador’s Ministry of Public Health. Comparative indicators were constructed between Ecuador and the Region of the Americas or Latin America and the Caribbean (LAC) for: (a) burden and elimination of selected NTDs; (b) recent dengue dynamics; and (c) WASH service coverage. A synthetic two‐panel table with key indicators was prepared, and an interpretive narrative analysis was conducted. Results Globally, NTD and malaria prevalence decreased 58% between 1990 and 2021, but the reduction in disability‐adjusted life years was only 18%, with a disproportionate burden still in low‐ and middle‐income regions. In the Americas, Ecuador was the second country to certify onchocerciasis elimination in 2014, following intensive mass drug administration (MDA) campaigns with ivermectin, with posttreatment surveillance confirming absence of transmission. The Region recorded a record dengue outbreak in 2024 with over 12.6 million suspected cases and more than 7700 deaths, concentrated in four large Latin American countries; through epidemiological Week 21 of 2025, more than 3 million cases had been reported, of which 23,623 corresponded to Ecuador. In 2020, 75% of the LAC population used safely managed drinking water and 34% used safely managed sanitation; nevertheless, 17 million people still lacked access to even basic water services and 72 million lacked basic sanitation. In Ecuador, basic drinking water‐service coverage reached 95.7% in 2022, but only 41.6% used safely managed sanitation, and in rural areas, substantial proportions of unimproved water sources, surface water use, and open defecation persist. According to GBD 2023 data, the age‐standardized DALY rate for NTDs and malaria combined was 193.8 per 100,000 in Ecuador (95% UI: 139.4–267.6), substantially lower than Bolivia (388.9) and Brazil (313.3). Conclusions Ecuador illustrates a regional paradox that is primarily institutional and programmatic rather than biological. Vertical programs endowed with a dedicated external initiative, a donated single‐dose drug, a verifiable elimination endpoint, and long‐term technical accompaniment—as in onchocerciasis—can interrupt transmission of a historical NTD, whereas the persistence of structural determinants—poverty, precarious urbanization, and WASH gaps—sustains the burden of other NTDs and arboviruses. PAHO’s Communicable Disease Elimination Initiative offers an opportunity to articulate elimination goals with rural water and sanitation policies, entomological surveillance, and intercultural territorial approaches. Sustained investments in WASH, integrated surveillance, and strengthened primary care are required to transform punctual elimination achievements into structural health equity gains.
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    Local thermal anomalies and the altitudinal rise of dengue hospitalisation rates in Ecuador, 2011–2024: a national ecological study
    Introduction Dengue is expanding beyond its traditional lowland range as rising temperatures may enable Aedes aegypti establishment at progressively higher altitudes. Ecuador, spanning sea level to above 4500 m, offers a natural altitudinal experiment, yet hospital-based evidence on the thermal drivers of Andean dengue is lacking. Methods We conducted a national ecological time-series analysis at the canton level using Ecuador's hospital discharge registry (INEC) for 2011–2024, the period with standardised canton coding, identifying dengue hospitalisations by ICD-10 codes A90, A91 and A97. Monthly land surface temperature, precipitation and vegetation index were derived from MODIS and GPM products. A distributed lag non-linear model estimated the temperature–hospitalisation association; a quasi-Poisson model restricted to Andean cantons (≥1500 m), with canton, calendar-month and year fixed effects, tested whether thermal anomalies above each canton's 2007–2015 baseline were associated with hospitalisation rates. Results Among 74,601 dengue hospitalisations with a resolvable canton of residence (232 deaths; case fatality 0.31%), dengue was recorded in 68 cantons above 1500 m, including altitudes exceeding 3000 m. The national hospitalisation rate rose from 29.7 to 77.0 per 100,000 and the Andean rate approximately 7-fold (1.9 to 12.8). The minimum hospitalisation temperature was 18.4°C nationally and 18.9°C in Andean cantons. A +1°C anomaly versus zero was associated with a 1.07-fold increase in hospitalisation rates (95% CI 1.02–1.13; p  = 0.012). Without canton fixed effects, the same contrast yielded 1.21 (1.07–1.36); the within-canton association fell to 1.04 (1.00–1.08) when the 2024 epidemic year was excluded. Discussion Positive deviations from local historical baselines, rather than absolute temperature, were associated with rising dengue hospitalisation rates among Andean residents, by a modest margin that depends materially on the 2023–2024 epidemic. In-hospital case fatality was nearly twice as high in low Andean cantons (0.62%, 95% CI 0.20–1.45; five deaths) as on the coast (0.33%), a non-significant difference that nonetheless supports strengthening dengue recognition in highland facilities.