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    Item type:Publication,
    Bioactive Natural Compounds in Triple-Negative Breast Cancer: Molecular Targets and Therapeutic Perspectives
    (2026)
    Emilia Jiménez-Flores
    ;
    Reytor González, Claudia  
    ;
    Dolores Jima Gavilanes
    ;
    Cesar Carrillo
    ;
    Raquel Horowitz
    Triple-negative breast cancer represents one of the most aggressive and therapeutically challenging subtypes of breast malignancies, characterized by marked biological heterogeneity, rapid progression, and limited targeted treatment options. Conventional therapies are frequently constrained by drug resistance, systemic toxicity, and high rates of recurrence. In this context, natural products have gained increasing attention as multifunctional agents capable of modulating several hallmarks of triple-negative breast cancer. Bioactive compounds, including polyphenols, terpenoids, alkaloids, and marine-derived molecules, exhibit pleiotropic antitumor effects by interfering with key oncogenic pathways. Importantly, these compounds have demonstrated the ability to counteract major mechanisms of therapeutic resistance, modulate the tumor immune microenvironment, and enhance the efficacy of standard chemotherapy and immunotherapy. Advances in drug delivery strategies, such as nanoparticle-based systems and tumor-targeted formulations, together with patient-specific molecular profiling, further expand the potential of these agents within personalized treatment approaches. This narrative review critically examines the role of natural compounds in targeting the hallmarks of triple-negative breast cancer and their potential synergistic use to improve therapeutic efficacy while reducing treatment-related toxicity. Overall, the integration of natural product-based strategies into precision oncology frameworks may offer more effective, less toxic, and individualized therapeutic options for this aggressive breast cancer subtype.
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    A Mini Review on Importance in the Implementation of Lean Management in Healthcare
    (2025)
    Tierra Arévalo, Marcelo  
    ;
    Valenzuela Cobos, Juan
    ;
    Grijalva Endara, Ana
    ;
    Garcés Moncayo, María
    Lean management contributes to pursuit the quality, accessibility and efficiency of healthcare institutions. Its importance of the implementation of lean management in the healthcare sector using different strategies to improve services like: the supply chain in hospitals. In this review was used the model proposed by seuring and gold based on the analyze a sample of articles indexed in Scopus, web of science and also the simulation tool was used to in order to illustrate the approach. After implementation of lean thinking in different hospital in some countries improves the structure, process and outcome of care and management actions and management in healthcare promotes advantages in terms of quality, safety and efficiency of healthcare in hospitals.
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