Reytor González, Claudia
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Reytor González, Claudia
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Ambato

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Hot flashes: a potential marker of deterioration of health-related quality of life

2026 , Juan E. Blümel , María S. Vallejo , Peter Chedraui , Eugenio Arteaga , Félix Ayala , Ascanio Bencosme , Calle Miñaca, Andrés , Lucia Costa-Paiva , Maribel Dextre , Karen Díaz , Alejandra Elizalde-Cremonte , Santiago Elizalde-Cremonte , Carlos Escalante , María T. Espinoza , Ircania García , Gustavo Gómez-Tabares , Hugo Gutiérrez-Crespo , Marcela López , Juan Matsumura-Kasana , Paolo Meza , Álvaro Monterrosa-Castro , Mónica Ñañez , Eliana Ojeda , Claudia Rey , Ana Lucia Ribeiro Valadares , Doris Rodríguez-Vidal , Marcio AH. Rodrigues , Javier Saavedra , Carlos Salinas , Lida Sosa , Konstantinos Tserotas , Margot Acuña-San Martín , Marcela S. Aguirre

Objective: Hot flashes are among the most common symptoms of the menopausal transition and have traditionally been considered benign and self-limiting. However, increasing evidence suggests that they may indicate broader neurovascular and inflammatory dysregulation linked to reproductive aging. The possible effect of hot flush severity on health-related quality of life (HRQoL) remains inadequately studied, particularly in Latin American populations. This study aimed to examine the association between hot flash severity and HRQoL in middle-aged women using validated tools and a large, multicenter sample. Method: A cross-sectional study was conducted between June 2024 and January 2025 in 30 healthcare centers across 12 Latin American countries. A total of 3523 women aged 40–60 years were assessed using the Menopause Rating Scale (MRS) to evaluate vasomotor symptoms and the Short Form-36 Health Survey (SF-36) to measure HRQoL. Multivariable logistic regression models were utilized to estimate the association between hot flush severity and low HRQoL, adjusting for sociodemographic, behavioral and clinical covariates. Results: Increasing severity of hot flushes was significantly associated with lower HRQoL scores across all SF-36 domains. In the logistic regression analysis, mild hot flushes (MRS item 1 score = 1) were associated with increased odds of impaired HRQoL (odds ratio [OR] 1.29; 95% confidence interval [CI]: 1.08–1.55), whereas very severe symptoms (MRS item 1 score = 4) demonstrated a substantially stronger association (OR 4.10; 95% CI: 2.93–5.74). Additional factors significantly associated with lower HRQoL included physical inactivity, the presence of comorbidities, obesity, current use of psychotropic medication, age ≥50 years and having two or more children. Conclusion: Hot flush severity is a strong and independent determinant of HRQoL in midlife women. These findings underscore the need for systematic assessment and targeted management of vasomotor symptoms in routine care, supporting the hypothesis that hot flashes may be a clinical marker of systemic aging. © 2026 International Menopause Society.

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Physical activity as an alternative or adjunct to menopausal hormone therapy for symptom management in women with primary ovarian insufficiency

2026 , Félix Ayala , Juan E. Blümel , María S. Vallejo , Peter Chedraui , Hugo Gutiérrez-Crespo , Marcela López , Juan Matzumura-Kasana , Paolo Meza , Álvaro Monterrosa-Castro , Mónica Ñañez , Eliana Ojeda , Claudia Rey , Ana Lucia Ribeiro Valadares , Doris Rodríguez-Vidal , Marcio A.H. Rodrigues , Javier Saavedra , Carlos Salinas , Lida Sosa , Konstantinos Tserotas , Margot Acuña-San Martín , Marcela S. Aguirre , Eugenio Arteaga , Ascanio Bencosme , Calle Miñaca, Andrés , Lucia Costa-Paiva , Maribel Dextre , Karen Díaz , Alejandra Elizalde-Cremonte , Santiago Elizalde-Cremonte , Carlos Escalante , María T. Espinoza , Ircania García , Gustavo Gómez-Tabares

Background: Physical activity alleviates menopausal symptoms in women whose menopause occurs after the age of 45; however, its effect in primary ovarian insufficiency, which occurs before the age of 40, remains unknown. Objective: To examine the association between physical activity, menopausal symptoms, and the use of menopausal hormone therapy in women with primary ovarian insufficiency. Methods: We analysed data from 4708 participants from two studies conducted in 12 Latin American countries. After applying eligibility criteria, 564 women with primary ovarian insufficiency (351 idiopathic and 213 surgical) were included. Menopausal symptoms were assessed using a validated scale, and severe symptoms were defined according to established cut-offs. Physical activity was classified according to international recommendations for moderate-intensity activity. Logistic regression models were adjusted for sociodemographic, clinical, and lifestyle variables. Results: The prevalence of severe menopausal symptoms was 39.2%, with no significant difference between idiopathic and surgical primary ovarian insufficiency. Women with severe symptoms were less likely to meet recommended levels of physical activity or to be current users of menopausal hormone therapy. In adjusted models, regular physical activity (OR 0.65; 95% CI 0.45–0.94) and current use of menopausal hormone therapy (OR 0.27; 0.17–0.42) were associated with a lower likelihood of severe symptoms, whereas obesity and use of psychotropic medication were associated with a higher likelihood. Conclusions: Women with primary ovarian insufficiency who engage in regular physical activity or currently use menopausal hormone therapy report less severe menopausal symptoms. Regular exercise may be an important non-hormonal option for women who cannot or prefer not to use hormone therapy. © 2026 Elsevier B.V.

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